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This effect appears to correlate with downregulation of genes encoding antigen processing components and 2M rather than downregulation of Class I genes themselves

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The American Academy of Dermatology lists soreness, redness, swelling, bruising, and an uncommon mild headache among possible temporary reactions after cosmetic botulinum toxin injections

Moreover, research shows that its low levels may be linked to Alzheimer's disease and other neurodegenerative conditions