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Acknowledgements The authors of this article are supported by grants from the American Heart Association (0930366N to R.C.), the American Diabetes Association (7-09-BS-17 and 7-12-BS-010 to C.B.), the Richard and Susan Smith Family Foundation Pinnacle Program Project (7-05-PPG-02 to C.B.), the Boston Obesity Nutrition Research Center (DK46200 to C.B.) and by grants from the US National Institutes of Health (DK080836 to R.C