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The Janus kinase (JAK)/STAT3 pathway as well as the activation of STAT3 through AKT kinase and mTOR are the important insulin/IGF-1-stimulated, STAT3-mediated signaling pathways which are able to control immunosuppression, immunosenescence, and insulin resistance (Figs

Brain struct Funct 226(1):225245 Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, Gospodarev V, Tang J, You C, Zhang JH (2018) Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

After cell lysis, cDNA synthesis was carried out (Maxima Reverse Transcriptase, Thermo Fisher), followed by PCR (2 Kapa Hotstart Ready mix, VWR, 15 cycles)