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Diarrhea specifically arises when the slowed-then-accelerated passage of food through the intestines overwhelms the colon's water-reabsorption capacity

The consistent signal is that both move a large majority of patients past clinically meaningful weight-loss thresholds

In some embodiments, the otic formulations and compositions described herein further comprise cholesterol

This idea is demonstrated by Figure 1 which compares the NMR solution structures of several IDPs serving as illustrations of the blurry view of IDP conformational ensembles from low-resolution methods with the crisp view of ordered proteins generated by high-resolution methods, such as X-ay crystallography and NMR