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Despite a reduction in potency relative to these standards, the observed GIPR activity suggests its potential as a molecular starting point for the rational design of triple-acting ligands (GLP-1R/GIPR/DOR)

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Together, these data suggest that GLP-1R agonism and GIPR antagonism may exert their effects on energy balance by downregulating signalling from DVC C35 GABA4 and C35 Glut10 neurons to hypothalamic feeding circuits

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