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Additionally, patients should be evaluated for other common causes of irritability, including sleep disorders, substance use, medication interactions, and underlying mental health conditions

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For example, supplementing with MSM significantly reduced inflammation in mice with stomach ulcers by inhibiting the release of inflammatory cytokines including TNF- and IL-6, as well as increasing glutathione levels ( Another study in 40 physically active men showed that taking 3 grams of MSM before exhaustive exercise decreased the release of inflammatory cytokines and prevented the over-stress of immune cells, compared to a placebo ( Summary MSM may reduce the release of molecules associated with inflammation, such as TNF- and IL-6, as well as boost levels of the powerful antioxidant glutathione