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1 and 3, are as follows: THF: tetrahydrofolate MS: methionine synthase BHMT: betaine-homocysteine methyltransferase MAT: methionine adenosyltransferase SAM: S-adenosylmethionine SAH: S-adenosylhomocysteine SAHH: SAH hydrolase ADA: adenosine deaminase AK: adenosine kinase CBS: cystathionine beta synthase B12: cyanocobalomine meB12: methylcobalamine 5-CH 3 THF: 5-Methyltetrahydrofolate Claims (5) 1

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Significantly, the expression of RAGE is markedly upregulated under various pathological circumstances, especially in atherosclerosis, diabetes mellitus, CVD, RA, Alzheimer's disease (AD), and immunerelated disorders [229,230,231,232,233]