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The levels of ghrelin, glucagon, Visfatin and Glp1 are decreased in the peritoneal fluid of women with endometriosis along with the increased expression of the CD10 protease by the macrophages

These are acidic, and their accumulation causes metabolic acidosis

b , Rotation of the superposed structures in a to view from extracellular space, the relative difference in orientation of the ECD is denoted

Our results provide a near-atomic level visualization of the molecular action of multi-targeting agonists on three cognate receptors and offer valuable information for the design of better drugs to combat metabolic diseases