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EC 2.5.1.18) constitute a large family of eukaryotic and prokaryotic metabolic isoenzymes that are profoundly known to be responsible for phase II detoxification by catalyzing the conjugation of xenobiotics to reduced glutathione (GSH), a low molecular weight thiol tripeptide that serves as the nucleophilic cosubstrate in GST-mediated reactions, thereby neutralizing toxic compounds and facilitating their elimination from the body via bile or urine (Coles and Ketterer 1990

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