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The work reported that colitis symptoms were ameliorated, together with reduced macroscopic damage, decreased mucosal inflammation, and tight junction barrier recovery

Excessive activation of MR leads to increased expression of pro-inflammatory and profibrotic genes, and generation of reactive oxygen species, contributory to tubular inflammation and fibrosis ( Overall, the activation of RAAS in DKD results in renal tubular injury through inflammation, hypoxia, fibrosis, and altered sodium and water handling