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This can cause oxidative stress and even trigger cell death.[ref] Low levels of BH4 are associated with several types of cardiovascular disease, including high blood pressure, heart disease, and cardiac hypertrophy

In the last decades, several studies have shown that patients with T2D treated with metformin had a reduction in cancer incidence (Yu et al., 2019)

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Enhanced phytoremediation of mixed heavy metal (mercury)organic pollutants (trichloroethylene) with transgenic alfalfa co-expressing glutathione S-transferase and human P450 2E1