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Arenas J, Ricoy JR, Encinas AR, Pola P, D'Iddio S, Zeviani M, Didonato S, Corsi M

Stubborn fat is usually about: genetics and fat distribution, hormones and insulin dynamics, training stimulus, total deficit consistency over time

402,403,404 Adipose tissue hypoxia and inflammation may lead to adipocyte dysfunction and obesity-induced insulin resistance in HFD-fed models, as indicated by increased infiltration of adipose tissue macrophages (ATMs), activation of the NLRP3 inflammasome and increased levels of proinflammatory cytokines

One area of particular interest is its applications in precision medicine, as it regulates inflammation without necessarily suppressing the immune system wholesale