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Acknowledgements The author thanks Morten Donsmark and Tine Bkdal (both Novo Nordisk A/S, Sborg, Denmark), and Kazushiro Fujiwara, and Eirik Quamme Bergan (both Novo Nordisk Pharma Ltd, Tokyo, Japan) for reviewing the manuscript, and to Andy Bond of Spirit Medical Communications Group Ltd for medical writing and editorial assistance (funded by Novo Nordisk A/S, Sborg, Denmark)