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The researchers found that turning off GLP-1 in the brain didnt affect the normal daily intake of food, but instead was important in several specific situations: prolonged fasting, large feedings, and stress-induced appetite loss.[ref] Controlling binging, regulating satiety: Essentially, the neurons activated by GLP-1 help to limit binging after a fast they keep you from massively overeating after not eating for a while

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While these drugs can be very effective, the first week is often a time of adjustment as your body gets used to the medication

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