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It is a vital enzyme in the Thymidylate Cycle, which recycles folate after its been used to generate thymidine

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5.3 Post-translational modification regulation of enzyme activity The activity of metabolic enzymes involved in the de novo serine synthesis pathway is precisely modulated by post-translational modifications such as methylation, ubiquitination and deacetylation ( Figure 3 ), and such regulatory patterns exhibit cancer-type specificity