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This together with the fact that patients showed treatment satisfaction in favor of injectable semaglutide rather than, e.g., injectable liraglutide in the SUSTAIN-10 trial (Capehorn et al., 2020), suggests that the higher proportion of patients discontinuing oral semaglutide treatment may be due to patients having to administer oral semaglutide once every day versus once a week with injectable semaglutide, making compliance for oral semaglutide more difficult and more expensive

Medically reviewed by Lauren Okafor | MD , The Frank H Netter MD School of Medicine, Loyola University Medical Center on February 26th, 2026

Dec 30, 2025 Amylin receptor agonists represent one of the most promising but least understood classes of weight loss peptides

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