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Cell 178 , 850866.e26 (2019)

A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

The combination creates a context where AOD 9604s lipolytic effect is occurring simultaneously with GH-stimulated protein synthesis and recovery, theoretically allowing fat loss and lean mass preservation to happen in parallel

Illustratively, BPC 157 (as an original anti-ulcer peptide, stable in human gastric juice more than 24 h unlike standard growth factors rapidly destroyed, and thereby easy applicable, lethal dose (LD1) not achieved, used to be in ulcerative colitis trials and now multiple sclerosis [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]), within wound/healing gastrointestinal ulcer relations and angiogenesis is advantageous over standard growth angiogenic factors [7]