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Studies show that the C667T and A1298C variants increase the relative risk : high homocysteine, stroke, and heart disease[ref][ref][ref][ref][ref] neural tube defects and cleft lip[ref] preeclampsia and hypertension in pregnancy[ref][ref] miscarriage[ref][ref] depression or anxiety[ref][ref][ref][ref][ref] Alzheimers[ref][ref] autism spectrum disorder (C677T only according to 2026 meta-analysis)[ref] rare problems with nitrous oxide[ref], but most have no problems[ref] Lets dig into the details of what research studies and clinical trials show
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Further studies are needed to define the optimal dose range of arctigenin and generate a no observed adverse effect level and a lowest observed adverse effect level
Vitamin D supplementation should be guided by serum 25-hydroxyvitamin D levels
