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Topical penetration is enhanced by vehicle formulation (e.g., liposomal encapsulation, penetration enhancers) but remains lower than subcutaneous or intravenous delivery

Namely, the irreversible monoamine oxidase (MAO B) inhibition (i.e., pargyline) and subsequent serotonin substrate (L-tryptophan as a serotonin precursor) induced fore paw treading, hind limbs abduction, wet dog shake, and hypothermia followed by hyperthermia in rats, which commonly occur in serotonin syndrome [66]

GHK-Cu works through different mechanisms than both treatments and combines safely with them

When performed by a trained provider with medical-grade product, correct dosing and sterile technique, GHK-Cu injections are generally safe and well tolerated