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Acknowledgements We acknowledge support from the National Institute on Alcohol Abuse and Alcoholism (AA029831), National Institute on Aging (AG057557, AG061388, AG062272, AG07664), from National Cancer Institute Case Comprehensive Cancer Center (CA221718, CA043703, CA2332216) Ethics declarations Competing interests The authors declare no competing interests

Research indicates that weight loss of 510% can meaningfully reduce intra-glomerular pressure and improve filtration stability