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Although significant differences in protein levels were not found between the UFMs in the current analyses, the observation from the larger validation cohort measured by Zhi et al (1139 type 1 diabetic individuals and 848 control individuals) may have benefited from the improved statistical power

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In a large clinical trial of SAMe (Mato 1999), patients with alcoholic cirrhosis on SAMe (1.2 g/day for 2 years) demonstrated a non-significant trend towards improvement in 2-year survival compared to control patients

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