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doi:10.1007/s13105-016-0491-7 82

Some even worsen the problem over time , especially stimulant laxatives that impair long-term bowel function

Bone health issues (stress fractures, decreased bone mineral density)

For example, one study demonstrated that endocannabinoid-like lipids can directly bind to GLP-1 and increase its potency via conformational changes 78