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9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution

Clinical data shows average weight loss of 1-2 pounds per week during the first 3 months, with pace often slowing thereafter as the body reaches new equilibrium points

Preparing an NDA typically takes 4 to 6 months after the last pivotal trial reports

Diabetes Care 33 , 15911597 (2010)