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The company was valued at about $7 billion as of early 2022, though that was before a steep drop in tech stocks and collapse in the initial public offering market forced many startups to dramatically lower their valuations

Patients with pre-existing cardiac conditions , particularly those with heart failure or significant arrhythmias, should be monitored appropriately when initiating GLP-1 receptor agonist therapy

Weeks 3-4: Drug is essentially cleared from the system

This positive chronotropic effect gained significance at 3 nM retatrutide (Fig