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Epub 2011 Aug 19

Serious adverse effects such as severe abdominal pain (which may indicate pancreatitis), persistent vomiting leading to dehydration, or signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness) require immediate medical attention

A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight

Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production