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The small-molecule nature of orforglipron provides manufacturing advantages (conventional chemical synthesis rather than peptide synthesis), stability advantages (no cold chain required, room temperature storage), and formulation flexibility (simple oral tablet, no SNAC enhancer)

The FDA will continue to actively monitor for violations of federal law involving the marketing of GLP-1 products and will take appropriate enforcement action against the manufacture, distribution and sale of illegal drug products, spokesperson Emily G

For people with hemophilia who are also managing type 2 diabetes or obesity, these drugs may be an appealing option

Both medications commonly cause gastrointestinal side effects and carry important warnings