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Indeed, a phase 2 mechanistic trial (NCT05936151) investigating change in eGFR from baseline to week 24 with multiple doses of retatrutide vs

They're shockingly effective, with a surprisingly low side effect profile, so much so that some people are left waiting for the other shoe to drop

"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial." The Lancet , 402(10404), 529-544

If this occurs, the area can become lumpy or scarred, which may prevent your body from absorbing the medication correctly in the future