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Administration of doses ranging between 3 and 8 g/day appears to be safe and does not induce immediate pharmacological effects in humans [32]

Severe gastrointestinal symptoms can lead to acute kidney injury, particularly in those with pre-existing kidney disease, older adults, or patients taking certain medications

doi: 10.1523/jneurosci.15-07-05389.1995 181 VeltkampR.PurruckerJ

By contrast, in diabetic retinopathy, 1,8-eudesmol alleviates retinal ferroptosis by suppressing TXNIP expression in a PPAR--dependent manner, thereby reducing oxidative stress and restoring the integrity of the blood-retinal barrier (97)