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Mitochondrial citrate is either exported to the cytosol via solute carrier family 25 transporters, notably the citrate transport protein (CTP) embedded in the inner mitochondrial membrane, to fuel cytosolic fatty acid and sterol biosynthesis, or retained intramitochondrially to contribute to ATP generation (72)

Nevertheless, there is a lack of the relevant cell lines to model the whole sophisticated cell interaction for both BBB and BCB, which is especially problematic for the latter since it is combined with a more model-challenging barrier geometry (Strazielle and Ghersi-Egea, 2011)

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