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[16] [17] While evidence is less robust, some studies suggest associations between RLS symptoms and deficiencies in vitamin B12, folate, and magnesium, though these links are not as well established as with iron

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Researchers have shown interest in these compounds for areas including: Cellular signaling Metabolic pathways Recovery and tissue biology Mitochondrial function Inflammatory pathways Exercise physiology The advisory committees recommendation reflects growing debate about how these substances should be regulated

Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC et al