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Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

Studies have also shown that infection with various helminth species can reduce the severity of diseases, including chemically-induced colitis (Fox et al., 2000

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The key rule is to make sure there are at least three days between two doses