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Notably, TZP was additionally correlated with reductions in patients' plasma lipid concentrations, waist circumferences, and fasting insulin levels

At the time, leptin was a highly anticipated treatment for obesity, but clinical trial results were disappointing

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

The ThymusNeuroendocrine Axis Type of study: literature review Number of citations: 32 Year: 2009 Authors: P