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Materials and methods Cell culture The human pancreatic cancer cell lines (CFPAC-1, SW1990, PANC-1, and BxPC-3) and murine pancreatic cancer cell line (Pan02) were procured from the Cell Bank of the Chinese Academy of Sciences Type Culture Collection (Shanghai, China)

The molecule with the best activity, 84 , proved to be a mixedtype XO inhibitor, and from in vitro tests, exhibited IC 50 values of 0.022 M, equivalent to topiroxostat, the drug used as a positive control (Figure 26)

Nature 401 , 657658 (1999)

If your BMI is between 27 and 29, you may still qualify if you have weight-related health conditions such as high cholesterol, high blood sugar, or an A1C of 5.7 or higher