switching to retatrutide from tirzepatide Navigating the Weight Loss Maze: vs. Switching from tirzepatide to retatrutide:

This results in increased skin laxity, leading to what is commonly referred to as Ozempic face. Or GLP-1 face When these fat pads shrink, the face may appear: More angular Less full in the cheeks or temples More hollow under the eyes More lined around the mouth and eyes For women ages 3555, these changes can appear more dramatic due to the natural collagen decline and an age-related drop in elastin

The response begins within 10 min but is generally slower than cephalic phase events and peaks after an hour

The focus shifted to GLP-1, with Svetlana Mojsov identifying its insulin-stimulating fragment, GLP-1(7-37), in 1983

N Engl J Med 385(10):896907