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Under insulin-sensitive conditions, insulin effectively stimulates skeletal muscle BCAA uptake and oxidation, promotes BCKDH complex activity, and accelerates BCAA catabolism (49)

Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways

In a validated operant mouse model of tinnitus, transient administration of RL-81 1 week after acoustic trauma mitigated the development of behavioral evidence of tinnitus, without affecting the underlying hearing loss (Marinos et al., 2021)

No private data or unverifiable claims were used