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If significant fibrosis is confirmed, patients should be referred to a specialist to perform liver biopsy and confirm the diagnosis histologically (59)

Many POPs are endocrinedisrupting chemicals, interfering with hormone receptors, thyroid signaling, steroid hormone synthesis, and epigenetic regulation

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(2017) "Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial" The Lancet Diabetes & Endocrinology, 5(4) This article was reviewed by and approved by Alice Fletcher, Lead Bariatric Dietitian, on 3 April 2025