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While passive diffusion was initially proposed as the main absorption route, recent evidence indicates that specific transmembrane transporters including Na-taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, L-type amino acid transporters, and monocarboxylate transporters also facilitate LT4 uptake
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Economic feasibility and industrial scalability of extraction techniques Conventional solvent extraction is widely used in industry because it is simple, cost-effective, and easy to scale up, however its efficiency is limited by high solvent usage, the need for solvent recovery, and environmental concerns related to organic solvents, which increase processing costs and regulatory challenges [119]
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