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When these receptors turn on in your intestines, they speed up how fast food moves through your colon, reducing water reabsorption and leading to loose or watery stools

The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction

During this syndrome, the change in airway muscle tone that promotes their collapse (mainly during the inspiratory phase of breathing) cannot be compensated by increasing their activity to maintain airway patency [1, 2]

PMID 33177239