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They operate in separate biological pathways: glutathione functions in cellular redox balance and Phase II detoxification, while tirzepatide modulates incretin signaling to reduce appetite and improve insulin sensitivity

The water molecule appeared to mediate an electrostatic interaction between Arg34 and Glu27

To first validate the negative control compound, we demonstrated that UNC12567 did not support ternary complex formation between FBXO22 and NSD2 over SEC (Supplementary Fig

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