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Currently, theres no evidence to suggest that drinking coffee interferes with this mechanism of action

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Urgent medical attention is needed for red flags such as unexplained weight loss, fever, focal neurological deficits, or inflammatory joint swelling

This double-blind, placebo-controlled study randomized adults with a BMI 30 or 27 plus at least one obesity-related comorbidity (excluding diabetes) who had achieved 5% weight loss after 12 weeks of lifestyle modification to receive tirzepatide or placebo weekly for 72 weeks