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Hepatol Baltim Md 2003, 37:14251434

Photic stimulation inhibits growth hormone secretion in rats: a hypothalamic mechanism for transient entrainment

The effects of H 2 S could be studied in large animal models, such as pigs and monkeys, which exhibit similar characteristics to human diseases, to provide a research foundation for clinical trials

This synergy is thought to result from complementary intracellular signalling mechanisms GHRH receptor activation increases cAMP via Gs coupling, while ghrelin receptor activation increases intracellular calcium and activates protein kinase C via Gq/11 coupling