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Cycle Guidelines Approach Standard Duration 8-12 weeks Off Period 4-8 weeks Best For General research context Approach Extended Duration 12-16 weeks Off Period 4-8 weeks Best For Longer observation windows Time off is commonly used to limit receptor desensitization

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If it impacts the testicular microenvironment, it could enhance sperm count or motility, but data are limited and the mechanism is different than how it might act in ovaries or endometrium

And by doing that, it helps preserve NAD + (key energy carrying molecule), SAM (universal methyl donor), and the downstream processes that depend on them