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This alteration, often caused by increased melanin production, can be permanent and is more common in those with lighter eye colors and older demographics

In response to nutrients, enteroendocrine L-cells and K-cells produce and release the incretin hormones including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), respectively [2]

Wagner, T

In contrast with GLP-1, there is a glycine at the second amino acid position in the N-terminus of Ex-4 that can protect the peptide against inactivation and degradation mediated by DPP-4 (130)