if semaglutide didn't work will tirzepatide or Tirzepatide: Which is Better for You? Switching from Semaglutide to Tirzepatide:

Patients who experience overwhelming side effects from rapid escalation often stop treatment prematurely, eliminating any short-term gain

2023 NEJM) used a one-week washout after tirzepatide or semaglutide before retatrutide initiation at 2 mg Plateau on the maximum tirzepatide dose for 6 months or more without further loss is the textbook switching indication

Stable Gastric Pentadecapeptide BPC 157, Roberts Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selyes Stress Coping Response: Progress, Achievements, and the Future

While it might not always be toxic, a discolored solution is a sign that the active ingredients are no longer stable