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Gouda MA, Duose DY, Lapin M, Zalles S, Huang HJ, Xi Y, Zheng X, Aldesoky AI, Alhanafy AM, Shehata MA, Wang J, Kopetz S , Meric-Bernstam F, Wistuba II, Luthra R, Janku F

GTP serves as the precursor for BH4 synthesis, a process requiring three enzymatic steps catalyzed by GCH1, 6-propylthio-tetrahydropterin synthase (PTS), and spirodactyl reductase (SPR), with GCH1 acting as the rate-limiting enzyme [64]

The roles of DNA, RNA and histone methylation in ageing and cancer

In the 38 years group, ATP7B, SLC31A1, FDX1, and DLD were significantly altered