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All participants received counseling (from qualified health care professionals, every 4-6 weeks, via in-person visits or telephone) to adhere to diet (500-kcal/d deficit relative to baseline estimated energy expenditure) and physical activity recommendations (150 minutes/week)

Maintains the natural moisture of the skin

The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

A damaged gut means compromised nutrient absorption, worsened immune function, and increased intestinal permeability which then drives more systemic inflammation