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However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

Hyperglycemia increases the production of Amyloid Beta-peptide leading to decreased endothelial tight junction

The use of natural, biocompatible exosomes as the delivery vehicle would mitigate many of the toxicity and immunogenicity concerns associated with synthetic nanoparticles, potentially making this a safer and more effective therapeutic strategy [35]