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Prevention of cardiorenal complications and beyond With the improvement in the management of cardiovascular risk factors, a progressive decline in the annual incidence rate of cardiovascular morbidity and mortality has been observed in both the general population and the diabetic population over the past decades
Understanding the bigger picture may help create more realistic expectations and more meaningful long-term recovery support.
Reclassification timing is uncertain
FIGURE 2 4.6.1 Nrf2/ARE pathway The Nrf2-antioxidant response element (Nrf2/ARE) pathway is pivotal in counteracting OS, a key driver of DN pathogenesis
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