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In addition to clinical trials, some TCMs, such as Rhodiola rosea , 393 Hippophae rhamnoides , 394 Aesculus chinensis , 395 Portulaca oleracea Linn ( Portulacaceae ), 396 Phlomis younghusbandii Mukerj ( Lamiaceae ), 397 Pueraria lobata , 398 Eleutheroside B , 399 and Notoginsenoside R1 , 400,401 showed promise in preventing HAPE/HACE in rat models by inhibiting the infiltration of inflammatory cells, the production of inflammatory cytokines, and apoptosis/pyroptosis

These include protective effects on the respiratory, reproductive, and cardiovascular systems, along with anti-hypoxic, anti-aging, anticancer, anti-inflammatory, and antioxidant properties (97)

It contains specially selected active ingredients such as niacinamide, glutathione, beta-glucan, hyaluronic acid, and a complex of ingredients derived from centella asiatica

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