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J Pharmacol Exp Ther 294:735745 Nepovm A, Podlipn R, Soudek P, Schrder P, Vanek T (2004) Effects of heavy metals and nitroaromatic compounds on horseradish glutathione S-transferase and peroxidase

Its important to note that not all constipation is "normal," even on GLP-1 medications

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For example, an individual with impaired fasting glucose who reduces visceral fat and decreases HbA1c by 0.5 to 1.0 percent can reduce their five-year diabetes risk significantly, especially when lifestyle change is sustained as well